Biochemistry & Nutrition

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Browsing Biochemistry & Nutrition by Author "Anandan, R"

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    Angiotensin-I converting enzyme (ACE) Inhibitory and Antioxidant peptides from Seafood Processing Waste
    (Society of Fisheries Techologies(India), 2021) Pavan Kumar, D; Elavarasan, K; Shamasundar, B.A; Anandan, R; Mathew,Suseela; Ravishankar, C.N
    Bioactive peptides are oligopeptides that contain 2–20 amino acid residues that can exhibit beneficial nutritional and physiological effects on human health. Protein hydrolysates or peptides derived from sea food processing waste with bioactive properties have been reported from different waste such as skin, fin, viscera, bone and air bladder. In vitro and controlled enzymatic hydrolysis of sea food processing waste using commercial enzymes as well as digestive proteases are the most employed for hydrolysis. The antihypertensive and antioxidant activities of bioactive peptides are influenced by several factors such as amino acid composition, hydrophobic amino acid residues, sequence and size. Most of the antihypertensive and antioxidant bioactive peptides from seafood have been investigated using in vitro and in vivo cell culture and animal models. This short review provides a comprehensive information of antihypertensive and antioxidant bioactive peptides from fish and fishery waste.
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    Is Marine ω-3 Long Chain Polyunsaturated Fatty Acids Intake, Natural Remedial Measure for Combating Global COVID-19 Pandemic?: A Mini-Review
    (SSR Inst. Int. J. Life Sci., 2021) Anandan, R; Jacob, M Rosemol; Fazil, TS; Ravishankar, CN; Mathew, Suseela
    COVID-19 is considered as the most public health emergency of international concern and global scientific research is on fast track to reduce the rise of epidemic curves. Marine natural bioactive molecules have been the starting point for the discovery of the most important drugs. The marine oils rich in ω-3 long chain polyunsaturated fatty acids (ω-3 LCPUFAs), especially, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well known to exert promising human healthcare benefits such as cardioprotective, antilipidemic, anti-inflammatory, anticancer, antiaging, antihypertensive, antidepression and antiarthritic properties. Interestingly, the immunomodulatory and anti-inflammatory potential of ω-3 LCPUFAs is capable of attenuating some of the COVID-19 mediated pathophysiological abnormalities through inhibition of proinflammatory processes. Understanding the basic mechanism of action of ω-3 LCPUFAs on pathophysiological conditions associated with COVID -19 may help address the pandemic related healthcare complications. Classical mechanism of action of ω-3 LCPUFAs in exhibiting anti-inflammatory properties is probably through counteraction of nuclear factor-kB activation, which is a transcription factor potentially involved in COVID-19 mediated of proinflammatory cytokine production. Also, dietary ω-3 LCPUFAs intake is well known to activate generation of resolvins and protectin, which in turn can suppress COVID-19 associated inflammation responses. Considering the beneficial actions of dietary intake of ω-3 LCPUFAs rich marine oils, this mini-review elaborates the physiologic and metabolic influences of ω-3 LCPUFAs on COVID-19 induced pathophysiological aberrations with relevance to their biochemical and molecular functions.
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    Nutritional and Biomedical Applications of Chitin and Chitosan: A Mini Review
    (Research Journal of Agricultural Sciences (RJAS), 2020) Rosemol Jacob, M; Mahadevan, R; Akshay, P; Anas, K K; Mathew, Suseela; Anandan, R
    The marine biopolymers, chitin and chitosan are prospective candidates possessing a widespread application in the field of clinical nutrition and biomedicine. The primary amine moieties present in the structural skeleton of chitin and chitosan pose pronounced physio-chemical and biological properties, which are profound to exert anticancer, antioxidant and antimicrobial functions, exploited in pharmaceutical and biomedical industries for the formulations of drugs and biomaterials. As these natural biopolymers exhibit diverse properties, they find potential attention in tissue engineering, wound healing process, microencapsulation and sustained drug delivery applications. The main emphasis of the present mini-review is to highlight the recent advancements on functional properties of chitin and chitosan with respect to nutritional and biomedical applications.