Whole genome sequence analysis of multi drug resistant community associated methicillin resistant Staphylococcus aureus from food fish: detection of clonal lineage ST 28 and its antimicrobial resistance and virulence genes

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dc.contributor.authorGopalan Krishnan Sivaraman
dc.contributor.authorVisnuvinayagam Sivam
dc.contributor.authorBalasubramanian Ganesh
dc.contributor.authorRavikrishnan Elangovan
dc.contributor.authorArdhra Vijayan
dc.contributor.authorMukteswar Prasad Mothadaka
dc.date.accessioned2026-05-25T08:51:18Z
dc.date.available2026-05-25T08:51:18Z
dc.date.issued2021-05-25
dc.description.abstractMethicillin-resistant staphylococcus aureus (MRSA) sequence type 28 (ST 28) and spa type t021 is a CC30, prototype of ST-30, Community Associated-MRSA (CA-MRSA) (lukS-lukF +). It is a multi-drug resistant strain harbouring staphylococcal endotoxins, haemolysins, ureolysin, serine protease, and antimicrobial resistance genes. In this study, we report the draft genome sequence of this MRSA isolated from the most commonly used food fish, ribbon fish (Trichiurus lepturus). The total number of assembled paired-end high-quality reads was 7,731,542 with a total length of 2.8Mb of 2797 predicted genes. The unique ST28/ t021 CA- MRSA in fish is the first report from India, and in addition to antibiotic resistance is known to co-harbour virulence genes, haemolysins, aureolysins and endotoxins. Comprehensive comparative genomic analysis of CA-MRSA strain7 can help further understand their diversity, genetic structure, diversity and a high degree of virulence to aid in fisheries management.
dc.identifier.citationSivaraman GK, Sivam V, Ganesh B, Elangovan R, Vijayan A, Mothadaka MP. Whole genome sequence analysis of multi drug resistant community associated methicillin resistant Staphylococcus aureus from food fish: detection of clonal lineage ST 28 and its antimicrobial resistance and virulence genes. PeerJ. 2021 May 24;9:e11224. doi: 10.7717/peerj.11224. PMID: 34113482; PMCID: PMC8158172.
dc.identifier.urihttps://drs.cift.res.in/123456789/6746
dc.language.isoen
dc.publisherPeerJ
dc.subjectResearch Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
dc.titleWhole genome sequence analysis of multi drug resistant community associated methicillin resistant Staphylococcus aureus from food fish: detection of clonal lineage ST 28 and its antimicrobial resistance and virulence genes
dc.typeArticle
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