Protective Effect of Fish Oil on 4-Nitroquinoline-1- Oxide (4NQO)-Induced Oral Carcinogenesis in Rats
Protective Effect of Fish Oil on 4-Nitroquinoline-1- Oxide (4NQO)-Induced Oral Carcinogenesis in Rats
Date
2010
Authors
Padma, V. Vijaya
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Fisheries Technologists (India)Cochin
Abstract
The present investigation was carried out to study the chemo-preventive potential of
fish oil against oxidative stress in 4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis
by measuring the levels of lipid peroxidation markers, antioxidants, and various serum
enzyme activities. Fish oil was administered for 15 days, and changes in the levels of lipid
peroxidation markers viz. malonaldehyde (MDA) and conjugated dienes (CD) and
antioxidants like superoxide dismutase, catalase, reduced glutathione, glutathione-Stransferase
and glutathione peroxidase were evaluated. The serum enzyme activities like
alanine transaminase, aspartate transaminase, lactate dehydrogenase, creatine phosphokinase
and alkaline phosphatase were also examined in normal and 4NQO-administered rats. A
significant increase in the activities of antioxidants and a decrease in the formation of MDA
and conjugated dienes were observed in oral tissues on treatment with fish oil. The
administration of fish oil also significantly reduced the serum enzyme activities. The
antioxidant effect of fish oil might be due to the incorporation of eicosapentaenoic acid which
is the major component of fish oil, into the membrane phospholipids of oral tissue, thus
protecting the cells from the oxidative stress induced by 4NQO
Description
Keywords
4NQO, fish oil, eicosapentaenoic acid (EPA), lipid peroxidation markers, antioxidants, serum enzyme activities
Citation
Fishery Tech47(1):51-56