FT Vol.58(4)

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Browsing FT Vol.58(4) by Author "K. K. Asha"

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    Cardio-protective effect of Thiamine and Pyridoxineloaded Vanillic acid grafted Chitosan micro-particlesagainst Isoproterenol-induced myocardial Infarction inanimal model
    (Society of Fisheries Technologists (India), 0201-11-24) C. S. Tejpal; K. Elavarasan; R. G. K. Lekshmi; N. S. Chatterjee; E. Sanal; H. M. Devi; K. K. Anas; K. K. Asha; R. Anandan; S. Mathew
    In the present study, the cardio-protective effect ofdietary supplementation of thiamine and pyridoxineloaded vanillic acid grafted chitosan microparticles(TPVGC) on isoproterenol induced myocardialinfarction in Wistar strain albino rats were studied.Animals were distributed into four experimentalgroups which were fed at graded level of levelsTPVGC for 45 days viz., Control (C) (basal feed + 0%TPVGC); T1 (basal feed + 0.8% TPVGC); T2 (basalfeed + 1.6% TPVGC); T3 (basal feed + 2.4% TPVGC)for experimental period of 45 days. The possible roleof dietary TPVGC on cardioprotective effect wasassessed in terms of Serum LDH, IgG, Homocys-teine, Serum Myglobin, troponin–T, CPK-MB, S-GOT, S-GPT, and other metabolic enzyme assays. Allthe assessed parameters were found to have signifi-cant difference between the control and treatmentgroups. The biochemical markers such as troponin–T, Serum LDH, CPK-MB, S-GOT, S-GPT, IgG,Homocysteine, Serum Myglobin exhibited signifi-cant (p<0.05) difference between the control andtreatment groups. Moreover, metabolic and antioxi-dant enzyme activity in the tissue levels also showedsignificant (p<0.05) difference between the controland treatment groups. Results from the presentstudy, revealed that dietary supplementation ofthiamine and pyridoxine loaded vanillic acid graftedchitosan microparticles at a minimum level of 1.6%have protective effect on experimental myocardialinfarction induced by isoprenaline in rats