Biochemistry & Nutrition

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Browsing Biochemistry & Nutrition by Subject "albino rats"

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    Effect of a long term feeding of a coconut oil based diet and a combined coconut oil - fish oil diet on serum cholestrol and fatty acid composition of different organs of albino rats
    (Association of Scientist and Techonologists (India), 1981) Nair, P.G.V.; Gopakumar, K.
    The influence of oil sardine (sardinella longiceps) and coconut oil together on the fatty acid composition of various organs and on the serum cholesterol level of albino rats was studied. Fatty acid pattern of the different organs was affected to varying extents by the dietary fatty acids. The level of arachidonic acid in the liver was found to be independent of the dietary supply of this acids, but appeared to be related to the level of linoleic acid in the diet. Dietary sardine was found to be very effective in lowering the serum cholesterol level even in the presence of a cholesterol-elevating agent such as coconut oil. This effect can be due to the high content of polyunsaturated acids in fish lipids as well as the nature of fish proteins.
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    Effect of centrophorus scalpratus liver oil against CFA-induced arthritis in albino rats
    (Central Institute of Fisheries Technology, 2011) Mathew, M.; Mathew, S.
    The objectives of the study conducted in Biochemistry & Nutrition Division of CIFT Cochin were to study the efficiency of Cemrophonts scalprahts (CS) liver oil against Complete Freund's Adjuvant-induced arthritis and to compare the anti-inflammatory activity of this oil with a traditionally used anti-inflarnmatory substance-gingerol (oleoresin extracted from ginger).
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    Effect of taurine on glucose metabolism in experimentally-induced fulminant hepatic failure in rats
    (Society of Fisheries Technologists (India), 2010) Asha, K.K.; Devadasan, K.
    Fulminant hepatic failure (FHF) is a devastating illness that has a high mortality rate and affects patients with previously healthy livers (Moreno- Gonzalez etal. 1995). Although an uncommon disorder, it is usually fatal and is defined as the occurrence of encephalopathy in a previously healthy person, within eight weeks from onset of severe liver disease. Although the etiology of FHF remains unclear, viral hepatitis and drug-induced liver injury account for the majority of causes. FHF caused by viral hepatitis is a national health problem in the developing countries. Hepatitis E causes large-scale epidemics of hepatitis in the Indian subcontinent, involving hundreds of thousands of cases with high mortality (Acharya et at., 2000; Khan et al., 2006) Clinical features of FHF can be divided into two broad groups: (i) manifestations of acute hepatic injury, namely, jaundice, shrunken liver, high liver enzymes, deficiency of clotting factors and other synthetic functions of the liver; and (U) multi-organ failure and a wide range of metabolic disturbances. All patients should be managed in an intensive care setting pending transfer to a liver transplantation center. Several issues namely selection of patients, appropriate timing of the transplant, the difficulty of making donor liver available within a short period of time, and postoperative course of these sick patients, and the fact that liver transplant should take place before severe irreversible brain damage has made transplantation for FHF a very challenging field (Turchetti, 2003). Despite this complexity, impressive recent progress has been achieved in advancing our understanding and appreciation of the cellular processes and mechanistic bases underlying fulminate hepatic failure. Effective clinical application of hepatoprotective and cytotrophic drugs may offer valuable time to provide a donor liver, or alternatively, to allow the native liver to regenerate.
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    Effects of peroxidised PUFA on tissue defence system in experimentally induced myocardial infraction in rats
    (Society of Fisheries Technologists(India),Cochin, 2003) Anandan, R.; Mathew, S.; Asha, K.K.; Ammu, K.; Nair, P.G.V.
    In the present study, the administration of peroxidised PUFA was found to aggravate the isoproterenol-induced myocardial infraction in rats, which was evident from the increased level protein and enhanced the release of marker enzymes in the serum of rats given PUFA and isoproterenol. It was also observed that oxidized PUFA in the diet resulted in higher levels of peroxidation and lower levels of antiperoxidative enzymes.
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    Influence of Vitamin E supplementation of dietary fish oils on lipid profile and blood glucose levels in albino rats
    (Association of Food Scientist and Technologists of India, 1996) Ammu, K.; Sankar, T.V.; Devadasan, K.
    Vitamin E supplementation of dietary sardine oil and shark liver oil was found to enhance the hypocholesterolemic properties and other favourable effects like reduction in serum triglycerides and increase in the percentage of HDL cholesterol in albino rats. The effect of diets having these oils with or without added vitamin E (1.5 IU/g) was compared to a sunflower oil diet and a commercial feed. The increase in the blood sugar levels in rats fed with polyunsaturated fatty acid (PUFA)-rich fish oil was insignificant. Influence of dietary fatty acids on the fatty acid composition of the lipids of heart, liver and adipose tissue of the rats fed on these diets is also reported