Protective effect of squalene isoproterenol-induced myocardial infarction in rats

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dc.contributor.authorFarvin, K.H.S.
dc.contributor.authorAnandan, R.
dc.contributor.authorSankar, T.V.
dc.contributor.authorNair, P.G.V.
dc.date.accessioned2013-06-15T10:31:31Z
dc.date.available2013-06-15T10:31:31Z
dc.date.issued2005
dc.description.abstractThe protective effect of squalane on membrane function and mineral status was examined in isoproterenol-induced myocardial infraction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the level of plasma diagnostic marker enzymes (ALS,AST,LDH and CPK), It countreacted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy.Supplimentation squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infraction by maintainig the activities of membrane-bound ATPases.in the heart tissue and the mineral status in plasma and heart tissue at near normal levels. The cardioprotective effect of squalane might be ascribable to its antioxidant nature and mambrane stabilizing properly.en_US
dc.identifier.citationJournal of Clinical Biochemical Nutrition 2005:37(2), 55-60en_US
dc.identifier.urihttp://hdl.handle.net/123456789/222
dc.language.isoenen_US
dc.publisherInstitute of applied biochemistry (Jappan)en_US
dc.subjectsqualeneen_US
dc.subjectisoproterenolen_US
dc.subjectmyocardial infarctionen_US
dc.subjectlipid peroxidationen_US
dc.titleProtective effect of squalene isoproterenol-induced myocardial infarction in ratsen_US
dc.typeArticleen_US
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