Peer Reviewed Journal Articles (Inter.) (B&N)
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- ItemIn vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste(Springer, 2021-05-16)The aim of the present study was to evaluate the ability of fish collagen peptides (FCP) derived from the skin of great hammerhead shark (Sphyrna mokarran) in attenuating the high fat diet-alcohol induced hyperlipidemia. The oral supplementation of FCP in high fat dietalcohol fed experimental rats confirmed the regulation of body weight to normal level. The FCP treated group revealed the efficient lipid lowering ability by enhancing the cholesterol metabolism. Western blot analysis of the lipid metabolic enzymes revealed that the oral-intake of FCP has down-regulated the expression levels of fatty acid synthase and 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR). Simultaneously, the expression levels of Lecithin–cholesterol acyltransferase (LCAT) in liver was up-regulated. Histopathology analysis of liver tissues demonstrated that the FCP treated group maintained normal liver parenchyma with moderate inflammatory infiltration, whereas the statin treated group developed centrilobular fibrosis, atrophy of hepatocytes and moderate inflammatory infiltration. Oral dietary supplementation of FCP enhanced the activity levels of both superoxide dismutase and catalase enzymes and, lowered the levels of lipid peroxidation in liver tissues.
- ItemPufferfish poisoning from Arothron stellatus: The first confirmed case in India with exact DNA sequencing-based species identification(Elsevier, 2021-09)A puffer fish poisoning case was reported from the coastal city of Veraval in the Gujarat state of India with patient reporting symptoms of giddiness, vertigo, aphasia and heaviness of head following consumption of cooked fish. Treatment was purely symptomatic and supportive. The patient was discharged from the hospital in a stable condition after 4 days. The suspected fish species was later identified using DNA (Deoxyribonucleic Acid) sequencing as Arothron stellatus with 100% identity.
- ItemTrace-minerals and lipid quality indices in seaweeds growing at Okha, India: A health risk assessment(Elsevier, 2021-07-12)A study was conducted to determine the presence of trace elements and heavy metals in marine macrophytes belonging to chlorophyceae and phaeophyceae collected from Okha, India, the North-eastern Arabian Sea. The result shows there is a mark of difference in the metal content among the seaweeds of different groups.In green seaweeds i.e chlorophyceae the trend of mineral content was Fe>Al>Zn>As>Pb>Cu>Cr and Cd, whereas the trend in phaeophyceae was Fe>Al>Zn>As>Cu>Pb>Cr>Cd. The Hazard Quotient (HQ) and Total Hazard Index (THI) were < 1, the Metal Pollution Index (MPI) were 0.83 (Ulva reticulata) to 7.39 (Padina tetrastromatica) . The result of MPI indicates that there is very-low to low contamination of heavy metals in the seaweeds. The cardiovascular indices of lipid viz. AI (Index of atherogenicity) (0.27-1.0), TI (Index of thrombogenicity) (0.13–0.41) were low and HH (Hypocholesterolomic/Hypercholesterolemic) (2.38– 4.15)& UI (Unsaturation Index) (183.09-236) was high. The overall result indicates that the seaweed studied can be recommended for consumptions.
- ItemExtraction and Characterization of Myofibrillar Proteins from Different Meat Sources: A Comparative Study(Elsevier, 2021-04-07)In the present study, myofibrillar proteins were extracted from the meat proteins of beef, lamb, chicken, tuna and emperor fish using non-denaturation method, and their physico-chemical and rheological properties were assessed. The myofibrillar proteins of beef, emperor and lamb samples had higher percentage of protein extractability than tuna and chicken samples. The tuna sample showed significantly higher bound bromophenol blue (BPB) value while lamb samples showed lower value ( P < 0.05). The myofibrillar protein of chicken sample was found to have more ionic and hydrogen bonds than all other myofibrillar samples. The disulphide bonds in tuna and lamb myofibrillar protein samples were significantly higher than other three samples ( P < 0.05). The myofibrillar protein samples showed major bands myosin heavy chain, 𝛼-actinin, desimin, actin, troponin, tropomyosin and myosin light chain with wider molecular weight distribution in the range of 20–200 ku. The myofibrillar proteins exhibited Newtonian and shear thickening nature behaviour at lower protein concentration (1 mg/mL) as revealed by flow profile and visco-elastic analysis using rheometer.
- ItemSynthesis of Biomaterial-Based Hydrogels Reinforced with Cellulose Nanocrystals for Biomedical Applications(Hindawi, 2021)Cellulose nanocrystals (CNC) were prepared by formic acid hydrolysis and TEMPO- (2,2,6,6-tetramethyl-piperidine-1-oxyl-) mediated oxidation. The prepared CNCs were reinforced into biopolymers chitosan (CHI), alginate (ALG), and gelatin (GEL) to obtain “CNC-ALG-GEL” and “CNC-CHI-GEL” hydrogels. The synthesized hydrogels were characterized for physicochemical, thermal, and structural characterization using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermal gravity analysis (TGA), and X-ray diffraction (XRD) analyses. Notably, the reinforcement of CNC has not altered the molecular structure of a biopolymer as revealed by FT-IR analysis. The hydrogels reinforced with CNC have shown better thermal stability and miscibility as revealed by thermal gravity analysis. The physicochemical, thermal, and structural characterization revealed the chemical interaction and electrostatic attraction between the CNC and biopolymers. The biocompatibility was investigated by evaluating the viability of the L929 fibroblast cell, which represents good biocompatibility and nontoxic nature. These hydrogels could be implemented in therapeutic biomedical research and regenerative medicinal applications.