Peer Reviewed Journal Articles (Inter.) (B&N)
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- ItemOptimum dietary levels of lysine and methionine reduces the crude protein requirement and improves growth in Snubnose pompano (Trachinotus blochii)(Elsevier, 2022-06-26)This study was aimed to test the effects of lysine (Lys) and methionine (Met) intake at different dietary protein levels (36, 38, and 40 g/100 g crude protein) on growth and metabolism in the juveniles of silver pompano (Trachinotus blochii). The experiment comprised six diets with different protein levels (CP 36, 38, and 40 g/100 g) without (D1, D2, D3) and with (D4, D5, D6) the supplementation of crystalline Lys (2.40 g/100 g) and Met (1.19 g/100 g). The diets were fed to the juveniles of silver pompano (average initial weight of 4.69 g) stocked in a recirculatory aquaculture system. After the feeding trial, the growth and nutrient utilization parameters in terms of weight gain percentage (WG %), specific growth rate (SGR), feed efficiency (FE) and protein efficiency ratio (PER) increased significantly (P < 0.05) with an increase in the dietary crude protein levels and supplementation of Lys and Met. There were no significant differences in the growth and feed utilization among the groups D3, D4, D5 and D6, while the lowest values were observed in D1 (weight gain = 288.31%, SGR=1.50, FE=0.40). However, no significant differences were found in the levels of serum triglycerides, hepatosomatic index (HSI), viscerosomatic index (VSI), serum cholesterol, serum albumin- to- globulin ratio (A: G) and whole-body lipid and moisture contents. In conclusion, the supplementation of optimum levels of Lys (2.40 g/100 g) and Met (1.19 g/100 g) in feed, with dietary protein level of 38 g/100 g, is sufficient for silver pompano and was found to result in better growth.
- ItemAntioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats(Elsevier, 2021-11-17)The aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis, as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and catalase and by lowering the levels of membrane lipid peroxidation.
- ItemNano-encapsulation of curcumin in fish collagen grafted succinyl chitosan hydrogel accelerates wound healing process in experimental rats(Elsevier, 2022-03-01)Succinyl chitosan-fish collagen composite hydrogel containing nano-encapsulated curcumin was developed for wound healing application. Curcumin was encapsulated in succinyl chitosan nano-particles using ionic gelation technique. The Z-average diameter of the nanoparticles as observed by dynamic light scattering experiment was ∼47 nm. Similar size ranges were observed in atomic force microscope (AFM) and transmission electron microscopy (TEM) images. A simple one pot gelation of the composite hydrogel containing nano-encapsulated curcumin was achieved by crosslinking succinyl chitosan and fish collagen with caffeic acid. The scanning electron microscopy (SEM) images of the crosslinked hydrogel showed porous sheet like/spongy morphology typical to crosslinked hydrogels. The developed hydrogel was evaluated for its wound healing efficacy in subcutaneous wound model on Wistar albino rats. The hydrogel significantly enhanced the collagen deposition and hydroxyproline content of 599.4 μg/gm and 74.9 μg/gm in wound tissue on the 14th day of post wounding.
- ItemBioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review(Elsevier, 2022-05-12)Background: The wide range of health benefits and variety of biological activities of carotenoids have made them the focal point of industrial as well as academic research on a global scale. Astaxanthin which is a ketocarotenoid is found in a few varieties of bacteria, fungi, yeast, algae, crustaceans, and fishes. Due to its potent biological activity specifically its ability to protect from reactive oxygen species in the living system, it is proven to be the most effective anti-oxidant with a range of bioactivities. Scope and approach: The present review is focused on the recent advances in the biomedical advantages of natural astaxanthin viz its anti-oxidant, anti-inflammatory, wound healing, cardioprotective, hepatoprotective, antidiabetic, neuroprotective, anti-carcinogenic and osteoprotective. An overview of bioavailability and future perspectives of astaxanthin is also highlighted. Key findings and conclusions: Important sources of natural astaxanthin as a potent nutraceutical have been explored. The natural form of astaxanthin is found to be more biologically active than its synthetic counterpart. Several research initiatives are in vogue worldwide on astaxanthin viz its natural sources, efficient methods of extraction and various biological activities that are helpful to use it in food and pharmaceutical industries.
- ItemCarrageenan, a marine sulphated polysaccharide, chemical modifications and anti-viral prospects - Review(International Journal of Chemistry, Material and Environmental Research (IJCMER), 2022)Marine realm constitutes diverse resource of bioactive compounds with significant bioactivity. Sulfated polysaccharides from seaweeds such as carrageenanare reported to pose excellent rheological properties. Despite thewide spectrum of usage as additives in the food, cosmetics and pharmaceutical industry, they acquire great developmental prospects in the area of virology. Modulation of structural characteristic of carrageenan have demonstrated remarkable rheological and chemical properties. This review focus on the modulation of structural characteristics of carrageenan with recent insights on enhancement of anti-viral property which gains significance for their application in the area of virology. Presently, there exists scant information on the pharmacology of carrageenan. Therefore, extensive research is required to explore them for the formulation of effective and safe drugs to combat the existing ailments and several novel diseases.Sulfated polysaccharides including carrageenan demonstrate a number of biological activities including antiviral properties.From the reviewed literature, it is concluded that chemical modulation of carrageenan structural characteristichasmanipulated its rheological and chemical properties and are found effective against several group of viruses including influenza A virus, human immunodeficiency virus and numerous others. The current mini review presents the anti-viral prospectives of carrageenan and induces insights to develop effective medication against novel viruses.