Peer Reviewed Journal Articles (Inter.) (B&N)
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- ItemBioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review(Elsevier, 2022-05-12)Background: The wide range of health benefits and variety of biological activities of carotenoids have made them the focal point of industrial as well as academic research on a global scale. Astaxanthin which is a ketocarotenoid is found in a few varieties of bacteria, fungi, yeast, algae, crustaceans, and fishes. Due to its potent biological activity specifically its ability to protect from reactive oxygen species in the living system, it is proven to be the most effective anti-oxidant with a range of bioactivities. Scope and approach: The present review is focused on the recent advances in the biomedical advantages of natural astaxanthin viz its anti-oxidant, anti-inflammatory, wound healing, cardioprotective, hepatoprotective, antidiabetic, neuroprotective, anti-carcinogenic and osteoprotective. An overview of bioavailability and future perspectives of astaxanthin is also highlighted. Key findings and conclusions: Important sources of natural astaxanthin as a potent nutraceutical have been explored. The natural form of astaxanthin is found to be more biologically active than its synthetic counterpart. Several research initiatives are in vogue worldwide on astaxanthin viz its natural sources, efficient methods of extraction and various biological activities that are helpful to use it in food and pharmaceutical industries.
- ItemCarrageenan, a marine sulphated polysaccharide, chemical modifications and anti-viral prospects - Review(International Journal of Chemistry, Material and Environmental Research (IJCMER), 2022)Marine realm constitutes diverse resource of bioactive compounds with significant bioactivity. Sulfated polysaccharides from seaweeds such as carrageenanare reported to pose excellent rheological properties. Despite thewide spectrum of usage as additives in the food, cosmetics and pharmaceutical industry, they acquire great developmental prospects in the area of virology. Modulation of structural characteristic of carrageenan have demonstrated remarkable rheological and chemical properties. This review focus on the modulation of structural characteristics of carrageenan with recent insights on enhancement of anti-viral property which gains significance for their application in the area of virology. Presently, there exists scant information on the pharmacology of carrageenan. Therefore, extensive research is required to explore them for the formulation of effective and safe drugs to combat the existing ailments and several novel diseases.Sulfated polysaccharides including carrageenan demonstrate a number of biological activities including antiviral properties.From the reviewed literature, it is concluded that chemical modulation of carrageenan structural characteristichasmanipulated its rheological and chemical properties and are found effective against several group of viruses including influenza A virus, human immunodeficiency virus and numerous others. The current mini review presents the anti-viral prospectives of carrageenan and induces insights to develop effective medication against novel viruses.
- ItemEncapsulation and Protection of Omega-3-Rich Fish Oils Using Food-Grade Delivery Systems(Multidisciplinary Digital Publishing Institute(MDPI), 2021-07-06)Regular consumption of adequate quantities of lipids rich in omega-3 fatty acids is claimed to provide a broad spectrum of health benefits, such as inhibiting inflammation, cardiovascular diseases, diabetes, arthritis, and ulcerative colitis. Lipids isolated from many marine sources are a rich source of long-chain polyunsaturated fatty acids (PUFAs) in the omega-3 form which are claimed to have particularly high biological activities. Functional food products designed to enhance human health and wellbeing are increasingly being fortified with these omega-3 PUFAs because of their potential nutritional and health benefits. However, food fortification with PUFAs is challenging because of their low water-solubility, their tendency to rapidly oxidize, and their variable bioavailability. These challenges can be addressed using advanced encapsulation technologies, which typically involve incorporating the omega-3 oils into well-designed colloidal particles fabricated from food-grade ingredients, such as liposomes, emulsion droplets, nanostructured lipid carriers, or microgels. These omega-3-enriched colloidal dispersions can be used in a fluid form or they can be converted into a powdered form using spray-drying, which facilitates their handling and storage, as well as prolonging their shelf life. In this review, we provide an overview of marine-based omega-3 fatty acid sources, discuss their health benefits, highlight the challenges involved with their utilization in functional foods, and present the different encapsulation technologies that can be used to improve their performance.
- ItemBiomodulation of poly (vinyl alcohol)/starch polymers into composite‑based hybridised films: physico‑chemical, structural and biocompatibility characterization(Springer Nature, 2021-06-25)The aim of present research work was to bio-modulate Poly (vinyl alcohol)/Starch (PVA/S) polymers and synthesize compositebased PVA/S hybridised films incorporated with ZnO, TiO2 and gelatin protein hydrolysate (GPH) components. The prepared PVA/S based composite hybridised films were characterized for physico-chemical, thermal and structural characterisation using Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Thermal gravity analysis (TGA), and X-ray diffraction (XRD) analyses. Notably, the incorporation of composites has made certain physico- chemical and structural modifications but not altered the molecular structure of biopolymer as revealed by FTIR analysis. The gelatinized blends of PVA/S based hybridised composite films incorporated with ZnO, TiO2 and GPH components have shown better thermal stability and miscibility as revealed by thermal gravity analysis. The biocompatibility was investigated by evaluating viability of L929 fibroblast cell, which had good biocompatibility and was non-toxic in nature. These PVA/S based composite hybridised films could be implemented in therapeutic biomedical research and food industrial applications.
- ItemNanoencapsulation in low-molecular-weight chitosan improves in vivo antioxidant potential of black carrot anthocyanin(Wiley, 2021-02-10)Anthocyanins are flavonoids that are potential antioxidant, anti-inflammatory, anti-obesity, and anticarcinogenic nutraceutical ingredients. However, low chemical stability and low bioavailability limit the use of anthocyanins in food. Nanoencapsulation using biopolymers is a recent successful strategy for stabilization of anthocyanins. This study reports the development, characterization, and antioxidant activity of black carrot anthocyanin-loaded chitosan nanoparticles (ACNPs). RESULTS: The ionic gelation technique yielded the ACNPs. The mean hydrodynamic diameter d and polydispersity index PDI of chitosan nanoparticles and ACNPs were found to be d = 455 nm and PDI = 0.542 respectively for chitosan nanoparticles and d = 274 nm and PDI = 0.376 respectively for ACNPs. The size distribution was bimodal. The surface topography revealed that the ACNPs are spherical and display a coacervate structure. Fourier transforminfrared analysis revealed physicochemical interactions of anthocyanins with chitosan. The loading process could achieve an encapsulation efficiency of 70%. The flow behavior index η of encapsulated ACNPs samples revealed Newtonian and shear thickening characteristics. There was a marginal reduction in the in vitro antioxidant potential of anthocyanins after nanoencapsulation, as evidenced from 2,2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays. Interestingly, the in vivo antioxidant potential of anthocyanins improved following nanoencapsulation, as observed in the serum antioxidant assays. CONCLUSION: The optimized nanoencapsulation process resulted in spherical nanoparticles with appreciable encapsulation efficiency. The nanoencapsulation process improved the in vivo antioxidant activity of anthocyanins, indicating enhanced stability and bioavailability. The promising antioxidant activity of the ACNPs suggests a potential for utilization as a nutraceutical supplement.