In vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste
In vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste
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Date
2021-05-16
Authors
Divya K. Vijayan
Sreerekha Perumcherry Raman
Pavan Kumar Dara
Rosemol M. Jacob
Mathew, Suseela
Anandan Rangasamy
Ravishankar Chandragiri Nagarajarao
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Springer
Abstract
The aim of the present study was to evaluate the
ability of fish collagen peptides (FCP) derived from the
skin of great hammerhead shark (Sphyrna mokarran) in
attenuating the high fat diet-alcohol induced hyperlipidemia.
The oral supplementation of FCP in high fat dietalcohol
fed experimental rats confirmed the regulation of
body weight to normal level. The FCP treated group
revealed the efficient lipid lowering ability by enhancing
the cholesterol metabolism. Western blot analysis of the
lipid metabolic enzymes revealed that the oral-intake of
FCP has down-regulated the expression levels of fatty acid
synthase and 3-Hydroxy-3-methylglutaryl-CoA reductase
(HMGCR). Simultaneously, the expression levels of
Lecithin–cholesterol acyltransferase (LCAT) in liver was
up-regulated. Histopathology analysis of liver tissues
demonstrated that the FCP treated group maintained normal
liver parenchyma with moderate inflammatory infiltration,
whereas the statin treated group developed
centrilobular fibrosis, atrophy of hepatocytes and moderate
inflammatory infiltration. Oral dietary supplementation of
FCP enhanced the activity levels of both superoxide
dismutase and catalase enzymes and, lowered the levels of
lipid peroxidation in liver tissues.
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Citation
J Food Sci Technol. https://doi.org/10.1007/s13197-021-05118-0