Synthesis of Biomaterial-Based Hydrogels Reinforced with Cellulose Nanocrystals for Biomedical Applications

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dc.contributor.authorDara, Pavan Kumar
dc.contributor.authorRaghavankutty, Mahadevan
dc.contributor.authorDeekonda, Karthik
dc.contributor.authorVemu, Anil Kumar
dc.contributor.authorSivam, Visnuvinayagam
dc.contributor.authorMathew, Suseela
dc.contributor.authorRangasamy, Anandan
dc.contributor.authorChandragiri Nagarajarao, Ravishankar
dc.contributor.authorSubramanian,
dc.contributor.authorSenthilkumar
dc.date.accessioned2023-08-09T05:09:39Z
dc.date.available2023-08-09T05:09:39Z
dc.date.issued2021
dc.description.abstractCellulose nanocrystals (CNC) were prepared by formic acid hydrolysis and TEMPO- (2,2,6,6-tetramethyl-piperidine-1-oxyl-) mediated oxidation. The prepared CNCs were reinforced into biopolymers chitosan (CHI), alginate (ALG), and gelatin (GEL) to obtain “CNC-ALG-GEL” and “CNC-CHI-GEL” hydrogels. The synthesized hydrogels were characterized for physicochemical, thermal, and structural characterization using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermal gravity analysis (TGA), and X-ray diffraction (XRD) analyses. Notably, the reinforcement of CNC has not altered the molecular structure of a biopolymer as revealed by FT-IR analysis. The hydrogels reinforced with CNC have shown better thermal stability and miscibility as revealed by thermal gravity analysis. The physicochemical, thermal, and structural characterization revealed the chemical interaction and electrostatic attraction between the CNC and biopolymers. The biocompatibility was investigated by evaluating the viability of the L929 fibroblast cell, which represents good biocompatibility and nontoxic nature. These hydrogels could be implemented in therapeutic biomedical research and regenerative medicinal applications.
dc.identifier.citationhttps://doi.org/10.1155/2021/4865733
dc.identifier.urihttp://10.10.10.7:82/handle/123456789/6140
dc.language.isoen
dc.publisherHindawi
dc.titleSynthesis of Biomaterial-Based Hydrogels Reinforced with Cellulose Nanocrystals for Biomedical Applications
dc.typeArticle
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