Hypocholesterolemic effects of poly unsaturated fatty acid concentrate prepared from fish oil

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Date
1998
Authors
Nair, P.G.V.
Ammu, K.
Devadasan, K.
Journal Title
Journal ISSN
Volume Title
Publisher
Association of Food Scientist and technologists (India)
Abstract
Hypocholesterolemic effects of a concentrate of polyunsaturated fatty acids (pUFA) prepared from commercially available fish oi1were evaluated In albino rats. PUFA concentrate containing about 76% of total polyunsaturated acids (36% of docosahexaenoic acid, (DHA) and 23% of e1cosapent.aenoic acid, (EPA) was Incorporated In a hypercholesterolemic diet at 1% level and fed to rats for two different periods, viz., one month and three months. The results showed that one month was too short a period for the hypocholesterolemic effects to be manifested. Continuation of the same diet for three months resulted in lowering of serum cholesterol level to about 36% of that in the control group. Cholesterol content of the liver of the animals fed on PUFA-supplemented diet was more than two times that of the control group (2.71 and 1.17 g/100g. respectively). Total lipid content of the liver of the animals also showed a sim1iar trend, suggesting that n-3 PUFA probably would lower serum cholesterol levels by effective redistribution of total cholesterol between serum and tissues.
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Keywords
PUFA, fish oil, DHA, EPA, hypocholesterolernic effect
Citation
Journal of Food Science and Technology 1998:35(5), 403-407