Protective effect of squalene on certain lysosomal hydrolases and free amino acids in isoprenaline-induced myocardial infraction in rats

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dc.contributor.authorFarvin, K.H.S.
dc.contributor.authorSurendraraj, A.
dc.contributor.authorAnandan, R.
dc.date.accessioned2014-01-04T08:36:41Z
dc.date.available2014-01-04T08:36:41Z
dc.date.issued2010
dc.description.abstractThis study was aimed to evaluate the preventive role of squalene on free amino acids and lysosomal alterations in experimentally induced myocardial infarction in rats. The levels of lysosomal enzymes ( -glucuronidase, -galactosidase, -glucosidase, acid phosphatase and cathepsin D) in plasma and lysosomal fractions, hydroxyproline content and free amino acids in heart tissue were determined. Isoprenaline administration to rats resulted in decreased stability of the membranes which was reflected by significantly (p<O.OOl) lowered activity of -glucuronidase, -galactosidase, -glucosidase, acid phosphatase and cathepsin D in the lysosomal fraction with a concomitant increase in plasma. Significant (p<0.001) reduction was also observed in the levels of taurine and hydroxyproline with a concomitant increase in the levels of aspartate, glutamate and arginine in the heart tissue of isoprenaline administered rats compared to normal control rats. Pretreatment with squalene at 2% level along with feed for 45 days significantly (p<0.001) prevented these alterations in free amino acids, hydroxyproline and lysosomal hydrolases and maintained the rats at near normal. Thus, the results of this present study show that squalene protects the lysosomal membrane against isoprenaline induced oxidative stress. The overall cardioprotective effect of squalene is ascribable to its ability to strengthen myocardial membrane including lysosomal membrane by its membrane stabilizing action and consequent diminution in the liberation of hydrolytic enzymes or by cmmteraction of free radicals by its antioxidant nature.en_US
dc.identifier.citationInternational Journal of Pharmacology 2010: 6(2), 97-103en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1266
dc.language.isoenen_US
dc.publisherAsian Network for Scientific Informationen_US
dc.subjectLysosomal hydrolasesen_US
dc.subjecttaurineen_US
dc.subjecthydroxyprolineen_US
dc.subjectaspartateen_US
dc.subjectarginineen_US
dc.titleProtective effect of squalene on certain lysosomal hydrolases and free amino acids in isoprenaline-induced myocardial infraction in ratsen_US
dc.typeArticleen_US
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