Development of thiamine and pyridoxine loaded ferulic acid-grafted chitosan microspheres for dietary supplementation

Simple item page
dc.contributor.authorChatterjee, N.S.
dc.contributor.authorAnandan, R.
dc.contributor.authorMary, Navitha
dc.contributor.authorAsha, K.K.
dc.contributor.authorAshok kumar, K.
dc.contributor.authorSuseela Mathew
dc.contributor.authorRavishankar, C.N.
dc.date.accessioned2016-10-07T04:57:41Z
dc.date.available2016-10-07T04:57:41Z
dc.date.issued2016
dc.description.abstractTherapeutic potential of water soluble vitamins has been known for long and in recent times they are being widely supplemented in processed food. Phenolic acid-grafted chitosan derivatives can serve as excellent biofunctional encapsulating materials for these vitamins. As a proof of concept, thiamine and pyridoxine loaded ferulic acid-grafted chitosan microspheres were developed. Ferulic acid was successfully grafted on chitosan by a free radical mediated reaction and the structure was confirmed by FTIR and NMR analysis. When compared to FTIR spectra of chitosan, intensity of amide I (at around 1644 cm−1) and amide II (at around 1549 cm−1) bands in spectra of ferulic acid-grafted chitosan were found increased, indicating formation of new amide linkage. Strong signals at δ=6.3–7.9 ppm corresponding to methine protons of ferulic acid were observed in NMR spectra of ferulic acidgrafted chitosan, suggesting the successful grafting of ferulic acid onto chitosan. Grafting ratio of the derivative was 263 mg ferulic acid equivalent/g polymer. Positively charged particles zeta potential 31 mv) of mean diameter 4.5 and 4.8 μ, corresponding to number distribution and area distribution respectively were observed. Compact microspheres with smooth surfaces and no apparent cracks or pores were observed under scanning electron microscope. Efficient microencapsulation was further proved by X-ray diffraction patterns and thermal analysis. Preliminary anti-inflammatory activity of the vitamin-loaded microspheres was demonstrated.en_US
dc.identifier.citationJournal of Food Science and Technology 2016:53(1):551–560en_US
dc.identifier.urihttp://hdl.handle.net/123456789/2316
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectVitaminen_US
dc.subjectMicroencapsulationen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-inflammatoryen_US
dc.subjectPhenolic aciden_US
dc.titleDevelopment of thiamine and pyridoxine loaded ferulic acid-grafted chitosan microspheres for dietary supplementationen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Development of thiamine and pyridoxine loaded ferulic.pdf
Size:
2.66 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Peer Reviewed Journal Articles (National) (B&N)