Biocompatibility and histopathological evaluation of chitosan nanoparticles grafted fish gelatin bio‑nanocomposite membranes in rats

Simple item page
dc.contributor.authorKumar Dara, Pavan
dc.contributor.authorRaghavankutty, Mahadevan
dc.contributor.authorBalaraman, Ganesan
dc.contributor.authorMuhamed Ashraf, P.
dc.contributor.authorVisnuvinayagam, S.
dc.contributor.authorTejpal, C. S.
dc.contributor.authorMathew, Suseela
dc.contributor.authorChandragiri Nagarajarao, Ravishankar
dc.contributor.authorRangasamy, Anandan
dc.date.accessioned2022-04-01T09:56:50Z
dc.date.available2022-04-01T09:56:50Z
dc.date.issued2021
dc.description.abstractBiomodulation of biopolymeric materials for human healthcare is an active and promising area of research. In the present study, chitosan nanoparticles grafted fish gelatin bio-nanocomposite membranes were prepared and their physical and structural properties were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The particle size of the chitosan nanoparticles (Chi-NPs) was in the range of 83–193 nm. The porosity of bio-nanocomposite membranes was in the range of 50–58%. The swelling and equilibrium water content of composite membranes increased significantly. The microstructures of bio-nanocomposite membranes were welldefined with relatively smooth surface, interconnected pores and voids. The cytotoxicity of bio-nanocomposite membranes was investigated using L929 fibroblast cells, and results showed that the membranes were non-toxic and their cell viability percentages were substantially higher as compared to control. Implantation of these membranes was conducted by animal experimental studies, and the results confirmed that bio-nanocomposite membranes have the potential to embrace safety, cell promotion and proliferation. Histopathological examination suggested that the bio-nanocomposite membrane was completely absorbed and it had an ability to promote the formation of granulation tissue and enhance epithelialization. The results of the present investigation demonstrated that chitosan nanoparticles grafted fish gelatin bio-nanocomposite membranes have good potential for biomedical and tissue engineering applications.en_US
dc.identifier.citationIranian Polymer Journal , https://doi.org/10.1007/s13726-021-00947-4en_US
dc.identifier.urihttp://drs.cift.res.in/handle/123456789/5995
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectBio-modulationen_US
dc.subjectChitosanen_US
dc.subjectGelatinen_US
dc.subjectBio-nanocomposite membranesen_US
dc.subjectImplantation and histopathologyen_US
dc.titleBiocompatibility and histopathological evaluation of chitosan nanoparticles grafted fish gelatin bio‑nanocomposite membranes in ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Biocompatibility and histopathological evaluation of chitosan.pdf
Size:
4.73 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Peer Reviewed Journal Articles (Inter.) (B&N)