Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats
Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats
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Date
2021-11-17
Authors
Vijayan, Divya K.
P. R., Sreerekha
Dara, Pavan Kumar
B., Ganesan
Mathew, Suseela
R., Anandan
C.N., Ravisankar
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead
shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation
of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the
FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis,
as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker
interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to
modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and
catalase and by lowering the levels of membrane lipid peroxidation.
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Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry
Citation
https://doi.org/10.1007/s12192-021-01245-x