Biochemical studies on the antiulcer effect of glucosamine on antioxidant defense status in experimentally induced peptic ulcer in rats

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dc.contributor.authorSanthosh, S.
dc.contributor.authorAnandan, R.
dc.contributor.authorSini, T.K.
dc.contributor.authorMathew, P.T.
dc.contributor.authorThankappan, T.K.
dc.date.accessioned2013-05-31T06:11:21Z
dc.date.available2013-05-31T06:11:21Z
dc.date.issued2005
dc.description.abstractThe present study examined the antiucler effect of glucosamine on mucosal antioxidant defense system in ibuprofen-induced peptic ulcer in male albino rats.The number of lesions in the gastric mucosa, volume of gastric juice, acid output, peasin activity, lipid peroxides, reduced glutathione conttent and the activities of glutathione dependent antioxidant enzymes (glutathione peroxidase and glutathione-S-transferase)and antiperoxidative enzymes (catalase and superoxide dismutase)were determined. Prior oral administration of glucosamine significantly prevented the ibuprofen-induced increases in the number of lesions in the gastric mucosa, volume of gastric juice and acidity .It also maintained the activity of pepsin at near normal level.Oral pretreatment of glucosamine exerted a significant antioxidant effect by preventing ibuprofen-induced lipid peroxidation and by maintaining the levelof reduced glutathione and the activities of muscosal antioxidant enzymes at near normalcy.The results of the present investigation indicate that the antiulcer activity of glucosamine is related to its ability to neutralize the hydrochloric acid secreted into the stomach and to its antioxidant capability to inhit ibuprofen-induced lipid peroxidation.en_US
dc.identifier.citationJournal of Clinical Biochemistry and Nutrition 2005:37(2), 61-66en_US
dc.identifier.urihttp://hdl.handle.net/123456789/134
dc.language.isoenen_US
dc.publisherThe Society of Free radical Research, Japanen_US
dc.subjectglucosamineen_US
dc.subjectibuprofenen_US
dc.subjectulceren_US
dc.subjectacid outputen_US
dc.subjectantioxidant statusen_US
dc.titleBiochemical studies on the antiulcer effect of glucosamine on antioxidant defense status in experimentally induced peptic ulcer in ratsen_US
dc.typeArticleen_US
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