Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats

Simple item page
dc.contributor.authorAnandan, R.
dc.contributor.authorGanesan, B.
dc.contributor.authorObulesu, T.
dc.contributor.authorMathew, S.
dc.contributor.authorAsha, K.K.
dc.contributor.authorLakshmanan, P.T.
dc.contributor.authorZynudheen, A.A.
dc.date.accessioned2014-06-17T08:46:56Z
dc.date.available2014-06-17T08:46:56Z
dc.date.issued2013
dc.description.abstractAging has been defined as the changes that occur in living organisms with the passage of time that lead to functional impairment and ultimately to death. Free radical induced oxidative damage has long been thought to be the present study, an attempt has been made to study the salubrious effects of dietary supplementation of chitosan significantly reduced the age-associated dyslipidemic abnormalities noted in the levels of total cholesterol, and LDL-cholesterol in plasma and heart tissue. its administration significantly (P<0.05) attenuated the oxidative stress in the heart tissue of aged rats through the enzymatic (glutathione peroxidase (GPx) and glutathione (GSH) status at levels comparable to that of normal young rats. our results conclude that dietary intake of chitosan restores the depleted myocardial antioxidant status and suggest that it could be an effective therapeutic agent in treatment of age-associated disorders where hypercholesterolemia and oxidative stress are the major causative factors.en_US
dc.identifier.citationCell Stress and Chaperones 2013: 18, 121-125en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1763
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectchitosanen_US
dc.subjectagingen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant satusen_US
dc.titleAntiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
antiaging effect of dietary.pdf
Size:
688.76 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Peer Reviewed Journal Articles (Inter.) (B&N)