Collagen Biosynthesis in Osteoblast Cells Treated with Fish Collagen Peptides

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dc.contributor.authorHema, G. S.
dc.contributor.authorShyni, K.
dc.contributor.authorManu Prasad, M.
dc.contributor.authorNinan, George
dc.contributor.authorMathew, Suseela
dc.date.accessioned2022-04-06T06:23:53Z
dc.date.available2022-04-06T06:23:53Z
dc.date.issued2017
dc.description.abstractCollagen is one of the most widely used biomaterials in tissue engineering and regenerative medicine. To investigate the effect of fish collagen peptides on the formation of collagen proteins by mature osteoblast cells, human osteoblast cells were treated with collagen peptide in both time and dose dependent manner. The stimulatory effect of collagen peptide was confirmed by western blot and immunocytochemistry analysis. The results clearly indicate that the presence of fish collagen peptides led to a dose dependent increase in collagen synthesis by osteoblast cells upto a concentration of 0.6 mg ml-1. However native collagen or collagen free protein hydrolysate failed to stimulate the production of collagen in osteoblast cells. The results show a stimulatory effect of fish collagen peptides on the collagen biosynthesis in osteoblast cells and suggest a possible mechanism for the regulation of collagen turnover in joint tissues.en_US
dc.identifier.citationFishery Technology 54 : 107 - 111en_US
dc.identifier.urihttp://drs.cift.res.in/handle/123456789/6009
dc.language.isoenen_US
dc.publisherSociety of Fisheries Technologists (India)en_US
dc.subjectFish collagen peptidesen_US
dc.subjectosteoblast cellsen_US
dc.subjectcollagen quantificationen_US
dc.subjectwestern blottingen_US
dc.subjectimmunocytochemistryen_US
dc.titleCollagen Biosynthesis in Osteoblast Cells Treated with Fish Collagen Peptidesen_US
dc.typeArticleen_US
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