Supplementation of betaine attenuates HCI-ethanol induced gastric ulcer in rats

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dc.contributor.authorGanesan, B.
dc.contributor.authorYathavamoorthy, R.
dc.contributor.authorFarvin, K.S.H.
dc.contributor.authorAnandan, R.
dc.date.accessioned2014-01-10T10:26:51Z
dc.date.available2014-01-10T10:26:51Z
dc.date.issued2010
dc.description.abstractThe anti-ulcer effect of betaine was evaluated in rat model of HCI-ethanol induced gastric ulcer. Oral administration of HCI-ethanol caused a significant increase in the number of lesions in the gastric mucose, volume of gastric juice, acidity and decreased activity of the pepsin. An increased level of lipid peroxidation and diminished tissue antioxidant system was also observed . pre oral treatment with betaine (250 mg/kg/day for 21 days ) counteracted all these changes induced by HCI-ethanol and maintained the rats at near normalcy. The gastro protective potential was further confirmed by histopathological studies of the gastric mucosa. the anti-ulcergenic activity of betaine might be ascribable to its ability to neutralize the hydrochloride secreted into the stomach and/or to its free radical scavenging activity which protects the gastic mucosa against oxidative damage by decreasing lipid peroxidation and strengthening the mucosal barrier.en_US
dc.identifier.citationInternational Journal of Biological Chemistry 2010:4(2), 79-89en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1334
dc.language.isoenen_US
dc.publisherAsian Network for Scientific Informationen_US
dc.subjectBetaineen_US
dc.subjectulceren_US
dc.subjectacidityen_US
dc.subjectpepsinen_US
dc.subjectlipid peroxidationen_US
dc.subjectantioxidanten_US
dc.titleSupplementation of betaine attenuates HCI-ethanol induced gastric ulcer in ratsen_US
dc.typeArticleen_US
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