Salubrious effects of dietary supplementation of squalene and n-3 polyunsaturated fatty acid concentrate mitochondrial function in young and aged rats
Salubrious effects of dietary supplementation of squalene and n-3 polyunsaturated fatty acid concentrate mitochondrial function in young and aged rats
Date
2014
Authors
Obulesu, T.
Mathew, S.
Lakshmanan, P.T.
Krishna, G.
Lakra, W.S.
Anandan, R.
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Fisheries Technologists (India), Cochin, India
Abstract
The present study was designed to investigate the
salubrious effects of dietary supplementation of
squalene and n-3 polyunsaturated fatty acid concentrate
on mitochondrial function in liver tissue of
young and aged rats. The combined dietary supplementation
of squalene and polyunsaturated fatty
acids significantly attenuated age-associated inhibition
on the activities of mitochondrial tricarcarboxylic
acid (TCA) cycle enzymes (isocitrate dehydrogenase,
a-ketoglutarate dehydrogenase, succinate dehydrogenase,
and malate dehydrogenase) and respiratory
marker enzyme (NADH dehydrogenase)
and maintained the hepatic energy status at near
normal. Co-supplementation of squalene and n-3
PUFA exerted synergistic effect in counteracting the
reactive oxygen species in the liver mitochondria of
aged rats by maintaining the mitochondrial antioxidant
status at level comparable to that of young
controls. The results of the present investigation
have shown that the combined dietary intake of
squalene and PUFA concentrate is more effective in
ameliorating the age-associated aberrations as compared
to per se supplementation
Description
Keywords
aging, antioxidant defense, energy status, squalene, n-3 PUFA
Citation
Fishery Technology 2014: 51(2), 98-101