Conference papers (B&N)

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Browsing Conference papers (B&N) by Author "Devadasan, K."

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    Effect of n-3 polyunsaturated fatty acids on the fatty acid profile in rats
    (Society of Fishery Technologists (India), 1998) Nair, P.G.V.; Ammu, K.; Devadasan, K.
    Effect of a polyunsaturated fatty acid (PUFA) concentrate containing about 80 percentage free acids at a level of 1 percentage of the diet, on the fatty acid profile of the lipids of liver and heart of rats fed on it for a period of three months was investigated. Law levels of dietary PUFA influence fatty acid composition of the lipids in liver and heart. The pattern of changes was different in the two organs, indicating tissue specificity to n-3 PUFA.
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    Effect of taurine on glucose metabolism in experimentally-induced fulminant hepatic failure in rats
    (Society of Fisheries Technologists (India), 2010) Asha, K.K.; Devadasan, K.
    Fulminant hepatic failure (FHF) is a devastating illness that has a high mortality rate and affects patients with previously healthy livers (Moreno- Gonzalez etal. 1995). Although an uncommon disorder, it is usually fatal and is defined as the occurrence of encephalopathy in a previously healthy person, within eight weeks from onset of severe liver disease. Although the etiology of FHF remains unclear, viral hepatitis and drug-induced liver injury account for the majority of causes. FHF caused by viral hepatitis is a national health problem in the developing countries. Hepatitis E causes large-scale epidemics of hepatitis in the Indian subcontinent, involving hundreds of thousands of cases with high mortality (Acharya et at., 2000; Khan et al., 2006) Clinical features of FHF can be divided into two broad groups: (i) manifestations of acute hepatic injury, namely, jaundice, shrunken liver, high liver enzymes, deficiency of clotting factors and other synthetic functions of the liver; and (U) multi-organ failure and a wide range of metabolic disturbances. All patients should be managed in an intensive care setting pending transfer to a liver transplantation center. Several issues namely selection of patients, appropriate timing of the transplant, the difficulty of making donor liver available within a short period of time, and postoperative course of these sick patients, and the fact that liver transplant should take place before severe irreversible brain damage has made transplantation for FHF a very challenging field (Turchetti, 2003). Despite this complexity, impressive recent progress has been achieved in advancing our understanding and appreciation of the cellular processes and mechanistic bases underlying fulminate hepatic failure. Effective clinical application of hepatoprotective and cytotrophic drugs may offer valuable time to provide a donor liver, or alternatively, to allow the native liver to regenerate.
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    Hypocholesterolemic effect of fish proteins and fish oils in albino rats
    (Society of Fishery Technologists (India), 1982) Nair, P.G.V.; Devadasan, K.; Antony, P.D.
    Casein or fish proteins (from Nemipterus japonicus), as the main source of protein and groundnut oil or sardine as the main source of fat, were used in four different combinations in diets of four groups of 5 week-old albino rats to see their effect on the cholesterol levels in the serum, liver and heart of the animals. Casein groundnut oil group (control)had the highest level of serum cholesterol and casein-fish oil group, the lowest. Fish protein-groundnut oil-fed animals also showed a significantly lower level of serum cholesterol, suggesting a hypocholesterolemic effect in the case of fish protein also. However, in the case of fish protein-fish oil group, the lowering of cholesterol was not as pronounced as would be expected of a combined hypocholesterolemic effect of fish oil and fish protein. The pattern of increase in liver cholesterol levels. Significance of these finding are discused