Biochemistry & Nutrition

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Browsing Biochemistry & Nutrition by Author "Anandan Rangasamy"

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    In vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste
    (Springer, 2021-05-16) Divya K. Vijayan; Sreerekha Perumcherry Raman; Pavan Kumar Dara; Rosemol M. Jacob; Mathew, Suseela; Anandan Rangasamy; Ravishankar Chandragiri Nagarajarao
    The aim of the present study was to evaluate the ability of fish collagen peptides (FCP) derived from the skin of great hammerhead shark (Sphyrna mokarran) in attenuating the high fat diet-alcohol induced hyperlipidemia. The oral supplementation of FCP in high fat dietalcohol fed experimental rats confirmed the regulation of body weight to normal level. The FCP treated group revealed the efficient lipid lowering ability by enhancing the cholesterol metabolism. Western blot analysis of the lipid metabolic enzymes revealed that the oral-intake of FCP has down-regulated the expression levels of fatty acid synthase and 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR). Simultaneously, the expression levels of Lecithin–cholesterol acyltransferase (LCAT) in liver was up-regulated. Histopathology analysis of liver tissues demonstrated that the FCP treated group maintained normal liver parenchyma with moderate inflammatory infiltration, whereas the statin treated group developed centrilobular fibrosis, atrophy of hepatocytes and moderate inflammatory infiltration. Oral dietary supplementation of FCP enhanced the activity levels of both superoxide dismutase and catalase enzymes and, lowered the levels of lipid peroxidation in liver tissues.