Biochemistry & Nutrition

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Browsing Biochemistry & Nutrition by Subject "aging"

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    Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats
    (Springer, 2013) Anandan, R.; Ganesan, B.; Obulesu, T.; Mathew, S.; Asha, K.K.; Lakshmanan, P.T.; Zynudheen, A.A.
    Aging has been defined as the changes that occur in living organisms with the passage of time that lead to functional impairment and ultimately to death. Free radical induced oxidative damage has long been thought to be the present study, an attempt has been made to study the salubrious effects of dietary supplementation of chitosan significantly reduced the age-associated dyslipidemic abnormalities noted in the levels of total cholesterol, and LDL-cholesterol in plasma and heart tissue. its administration significantly (P<0.05) attenuated the oxidative stress in the heart tissue of aged rats through the enzymatic (glutathione peroxidase (GPx) and glutathione (GSH) status at levels comparable to that of normal young rats. our results conclude that dietary intake of chitosan restores the depleted myocardial antioxidant status and suggest that it could be an effective therapeutic agent in treatment of age-associated disorders where hypercholesterolemia and oxidative stress are the major causative factors.
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    Salubrious effects of dietary supplementation of squalene and n-3 polyunsaturated fatty acid concentrate mitochondrial function in young and aged rats
    (Society of Fisheries Technologists (India), Cochin, India, 2014) Obulesu, T.; Mathew, S.; Lakshmanan, P.T.; Krishna, G.; Lakra, W.S.; Anandan, R.
    The present study was designed to investigate the salubrious effects of dietary supplementation of squalene and n-3 polyunsaturated fatty acid concentrate on mitochondrial function in liver tissue of young and aged rats. The combined dietary supplementation of squalene and polyunsaturated fatty acids significantly attenuated age-associated inhibition on the activities of mitochondrial tricarcarboxylic acid (TCA) cycle enzymes (isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase) and respiratory marker enzyme (NADH dehydrogenase) and maintained the hepatic energy status at near normal. Co-supplementation of squalene and n-3 PUFA exerted synergistic effect in counteracting the reactive oxygen species in the liver mitochondria of aged rats by maintaining the mitochondrial antioxidant status at level comparable to that of young controls. The results of the present investigation have shown that the combined dietary intake of squalene and PUFA concentrate is more effective in ameliorating the age-associated aberrations as compared to per se supplementation