Effect of chittosan supplimentation on antitubercular drugs-induced hepatotoxicity in rats
Effect of chittosan supplimentation on antitubercular drugs-induced hepatotoxicity in rats
Date
2006
Authors
Santhosh, S.
Sini, T.K.
Anandan, R.
Mathew, P.T.
Journal Title
Journal ISSN
Volume Title
Publisher
Elseviar
Abstract
We have studied the protective effect of chitosan on isoniazid- and rifampicin-induced hepatotoxicity with respect to the changesin the levels of diagnostic marker enzymes (in serum), lipid components and lipid peroxidation (in serum and liver). The oraladministration of antitubercular drugs caused a significant elevation in the levels of diagnostic marker enzymes and cholesterol,
triglycerides, free fatty acids and lipid peroxidation in serum and liver of experimental rats. There was a slight decline in thelevel of phospholipids in liver tissue also observed.Co-administration of chitosan significantly prevented the antitubercular drugsinducedelevation in the levels of serum diagnostic marker enzymes (alanine amino transferase, aspartate amino transferase, lactatedehydrogenase, acid phosphatase and alkaline phosphatase) in experimental groups of rats. It exerted a significant antilipidemiceffect against isoniazid- and rifampicin-induced hepatitis by maintaining the levels cholesterol, triglycerides, free fatty acids and
phospholipids in serum and liver at near normalcy. A tendency to prevent the isoniazid- and rifampicin-induced lipid peroxidationwas also observed. The results of the present study indicated that the hepatoprotective effect of chitosan might be ascribable to itsantilipidemic effect and/or antioxidant property
Description
Keywords
chitosan, lipids
Citation
Toxicology 2006: 12(1), 53-59