Effect of chittosan supplimentation on antitubercular drugs-induced hepatotoxicity in rats

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dc.contributor.authorSanthosh, S.
dc.contributor.authorSini, T.K.
dc.contributor.authorAnandan, R.
dc.contributor.authorMathew, P.T.
dc.date.accessioned2013-09-03T06:54:11Z
dc.date.available2013-09-03T06:54:11Z
dc.date.issued2006
dc.description.abstractWe have studied the protective effect of chitosan on isoniazid- and rifampicin-induced hepatotoxicity with respect to the changesin the levels of diagnostic marker enzymes (in serum), lipid components and lipid peroxidation (in serum and liver). The oraladministration of antitubercular drugs caused a significant elevation in the levels of diagnostic marker enzymes and cholesterol, triglycerides, free fatty acids and lipid peroxidation in serum and liver of experimental rats. There was a slight decline in thelevel of phospholipids in liver tissue also observed.Co-administration of chitosan significantly prevented the antitubercular drugsinducedelevation in the levels of serum diagnostic marker enzymes (alanine amino transferase, aspartate amino transferase, lactatedehydrogenase, acid phosphatase and alkaline phosphatase) in experimental groups of rats. It exerted a significant antilipidemiceffect against isoniazid- and rifampicin-induced hepatitis by maintaining the levels cholesterol, triglycerides, free fatty acids and phospholipids in serum and liver at near normalcy. A tendency to prevent the isoniazid- and rifampicin-induced lipid peroxidationwas also observed. The results of the present study indicated that the hepatoprotective effect of chitosan might be ascribable to itsantilipidemic effect and/or antioxidant propertyen_US
dc.identifier.citationToxicology 2006: 12(1), 53-59en_US
dc.identifier.urihttp://hdl.handle.net/123456789/536
dc.language.isoenen_US
dc.publisherElseviaren_US
dc.subjectchitosanen_US
dc.subjectlipidsen_US
dc.titleEffect of chittosan supplimentation on antitubercular drugs-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US
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