Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats
Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats
Date
2006
Authors
Sabeena Farvin, K.H.
Anandan, R.
Hari Senthil Kumar, S.
Shiny, K.S.
Mathew, Suseela
Sankar, T.V.
Viswanathan Nair, P.G.
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert
Abstract
We studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino
rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene
in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, and
free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an anitlipidemic effect by reducing
the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol
in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium
of experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the isoprenaline-
induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate
that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipidemic
properties and/or its antioxidant properties.
Description
Keywords
Isoprenaline, lipid peroxidation, lipids, myocardial infarction, Squalene
Citation
JOURNAL OF MEDICINAL FOOD 9 (4) : 531–536