Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats

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dc.contributor.authorSabeena Farvin, K.H.
dc.contributor.authorAnandan, R.
dc.contributor.authorHari Senthil Kumar, S.
dc.contributor.authorShiny, K.S.
dc.contributor.authorMathew, Suseela
dc.contributor.authorSankar, T.V.
dc.contributor.authorViswanathan Nair, P.G.
dc.date.accessioned2022-04-06T10:34:27Z
dc.date.available2022-04-06T10:34:27Z
dc.date.issued2006
dc.description.abstractWe studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, and free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an anitlipidemic effect by reducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium of experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the isoprenaline- induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipidemic properties and/or its antioxidant properties.en_US
dc.identifier.citationJOURNAL OF MEDICINAL FOOD 9 (4) : 531–536en_US
dc.identifier.urihttp://drs.cift.res.in/handle/123456789/6014
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.subjectIsoprenalineen_US
dc.subjectlipid peroxidationen_US
dc.subjectlipidsen_US
dc.subjectmyocardial infarctionen_US
dc.subjectSqualeneen_US
dc.titleCardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Ratsen_US
dc.typeArticleen_US
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