Resistance of Escherichia coli and Salmonella isolated from marine and freshwater fishes towards Carbapenems
Resistance of Escherichia coli and Salmonella isolated from marine and freshwater fishes towards Carbapenems
Date
2014
Authors
Rao, M.B.
Murthy, L.N.
Jesmi, D.
Prasad, M.M.
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Fisheries Technologists (India), Cochin, India
Abstract
The carbapenems are beta-lactam antimicrobial agents
with an exceptionally broad spectrum of activity and
are active against most Enterobacteriaceae including
those that produce ampC b-lactamase. Resistance to
carbapenems, especially carbapenems-resistant-Enterobacteriaceae
(CRE) is a serious issue worldwide as
it is extremely difficult to combat bacteria resistant
to carbapenems. Fifty two isolates of Escherichia coli
and twelve isolates of Salmonella (invA and stn gene
positive) isolated from marine fish and freshwater
fish were tested for their susceptibility to carbapenems
namely meropenem, imipenem and ertapenem. A
low percentage (3.9%) of E.coli showed resistance to
meropenem, while 11.5 & 17% of E.coli and 8.3 &
25% of Salmonella showed intermediate sensitivity
to meropenem and ertapenem, respectively. However,
100% of E. coli and Salmonella were sensitive
to imipenem. Importantly, meropenem resistant
E.coli was also found to be resistant to other
antibiotics such as ciprofloxacin, gentamicin, nalidixic
acid, norfloxacin and tetracycline. The results
indicate that carbapenem resistance in E. coli and
Salmonella isolated from fish was marginal but
nevertheless needs continuous monitoring.
Description
Keywords
Carbapenems, meropenem, ertapenem, imipenem, Escherichia coli, Salmonella, antibiotic resistance
Citation
Fishery Technology 2014: 51(3), 207-212