Anti diabetic and anti hyperlipidemic activities of different extracts of ailanthus malabarica stem bark in alloxan induced diabetic rats
Anti diabetic and anti hyperlipidemic activities of different extracts of ailanthus malabarica stem bark in alloxan induced diabetic rats
Date
2015
Authors
Louis, T.
Yuvaraj, P.
Madhavachandran, V.
Anandan, R.
Journal Title
Journal ISSN
Volume Title
Publisher
Pharma Intelligence
Abstract
To evaluate the anti diabetic and anti hyperlipidemic activities of different extracts of Ailanthus malabarica stem bark in alloxan induced diabetic rats. Different extracts (hexane, ethanol and water, 50 mg/kg) of A. malabarica stem bark were administered to alloxan-induced diabetic rats for 21 days and blood glucose levels of the diabetic rats were monitored at one week intervals. Lipid profiles of the treated diabetic rats were determined after the period of treatment. Treatment of alloxan-induced diabetic rats with ethanol extract of A. malabarica stem bark caused a significant (P<0.05) reduction in fasting blood glucose levels of the diabetic rats in 21 days treatment. The ethanol extract showed a comparable action with the reference drug, glibenclamide. The ethanol extract exerted a significant reduction in the levels of serum total cholesterol, triglycerides, LDL, VLDL and phospholipids, and increase in HDL levels of the diabetic rats. However, water and hexane extract of A. malabarica stem bark did not show any such beneficial effects. . These results suggest that the ethanol extract of A. malabarica stem bark possesses anti diabetic effect on alloxan induced diabetic rats and this justifies its usage in ethno medicine and can be exploited in the management of diabetes.
Description
Keywords
antidiabetic, antihyperlipidimic, ailanthus malabarica, stem bark
Citation
International Journal of Biological & Pharmaceutical Research 2015: 6(5) 327-331