Protective Effects of Echinorhinus brucus Liver Oil against Induced Inflammation and Ulceration in Rats
Protective Effects of Echinorhinus brucus Liver Oil against Induced Inflammation and Ulceration in Rats
Date
2015
Authors
Vishnu, K.V.
Ajeeshkumar, K.K.
Asha, K.K.
Remyakumari, K.R.
Ganesan, B.
Anandan, R.
Chatterjee, N.S.
Suseela Mathew
Journal Title
Journal ISSN
Volume Title
Publisher
Central Institute of Fisheries Technology, Cochin, India
Abstract
Anti-inflammatory and anti-ulcer activities of Bramble shark (Echinorhinus brucus) liver oil were examined in rats. The oil showed significant proportion of n-3 polyunsaturated fatty acids (PUFAs), the percentages of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) being 16 and 18% respectively. The study also revealed that liver oil had a very favourable n3:n6 ratio of 4.7. Oral administration of shark liver oil at 1g kg-1 concentration significantly attenuated the formalin-induced paw edema in experimental rats. It exerted potent anti-ulcer effect against acid-ethanol mixturemediated lesion formation in the rat gastric mucosa.
Description
Keywords
Bramble shark, liver oil, anti-inflammation, anti-ulcer
Citation
Fishery Technology 2015: 52 (4), 252-257