Supplementation of squalene attenuates experimentally induced myocardial infraction in rats
Supplementation of squalene attenuates experimentally induced myocardial infraction in rats
Date
2007
Authors
Farvin, K.H.S.
Kumar, S.S.
Sankar, T.V.
Anandan, R.
Mathew, S.
Nair, P.G.V.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
We have investigated the preventive effects of squalene against isoprenaline-induced myocardial infarction in male albino rats. Supplementation with squalene significantly prevented the isoprenaline-induced adverse changes in the levels of protein and glycoprotein components in plasma and heart tissue of experimental groups of rats. It exerted an antioxidant effect by inhibiting the isoprenalineinduced lipid peroxidation and by maintaining the level of non-enzymatic free radical-scavenger, reduced glutathione at near normalcy. Histopathological observations also confirmed the possible cardioprotective action of squalene by maintaining the normal architecture of the heart tissue. The results of the present investigation demonstrate that supplementation with squalene offers cardioprotection in experimental rats by its antioxidant and membrane- stabilizing properties.
Description
Keywords
Squalene, isoprenaline, myocardial infarction, protein, glycoprotein components, lipid peroxidation
Citation
Food Chemistry 2007: 105, 1390-1395