Supplementation of squalene attenuates experimentally induced myocardial infraction in rats

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dc.contributor.authorFarvin, K.H.S.
dc.contributor.authorKumar, S.S.
dc.contributor.authorSankar, T.V.
dc.contributor.authorAnandan, R.
dc.contributor.authorMathew, S.
dc.contributor.authorNair, P.G.V.
dc.date.accessioned2013-12-27T09:03:54Z
dc.date.available2013-12-27T09:03:54Z
dc.date.issued2007
dc.description.abstractWe have investigated the preventive effects of squalene against isoprenaline-induced myocardial infarction in male albino rats. Supplementation with squalene significantly prevented the isoprenaline-induced adverse changes in the levels of protein and glycoprotein components in plasma and heart tissue of experimental groups of rats. It exerted an antioxidant effect by inhibiting the isoprenalineinduced lipid peroxidation and by maintaining the level of non-enzymatic free radical-scavenger, reduced glutathione at near normalcy. Histopathological observations also confirmed the possible cardioprotective action of squalene by maintaining the normal architecture of the heart tissue. The results of the present investigation demonstrate that supplementation with squalene offers cardioprotection in experimental rats by its antioxidant and membrane- stabilizing properties.en_US
dc.identifier.citationFood Chemistry 2007: 105, 1390-1395en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1103
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectSqualeneen_US
dc.subjectisoprenalineen_US
dc.subjectmyocardial infarctionen_US
dc.subjectproteinen_US
dc.subjectglycoprotein componentsen_US
dc.subjectlipid peroxidationen_US
dc.titleSupplementation of squalene attenuates experimentally induced myocardial infraction in ratsen_US
dc.typeArticleen_US
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