Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats
Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats
Date
2021
Authors
K Vijayan, Divya
Sreerekha, P R
Kumar Dara, Pavan
Ganesan, B
Mathew, Suseela
Anandan, Rangasamy
Ravisankar, C N
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
The aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis, as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and catalase and by lowering the levels of membrane lipid peroxidation.
Description
Keywords
Bioactivity, Gastroprotective, Great hammerhead shark, Gross pathology, Histopathology, Inflammatory markers
Citation
DOI: 10.1007/s12192-021-01245-x