Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats

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dc.contributor.authorK Vijayan, Divya
dc.contributor.authorSreerekha, P R
dc.contributor.authorKumar Dara, Pavan
dc.contributor.authorGanesan, B
dc.contributor.authorMathew, Suseela
dc.contributor.authorAnandan, Rangasamy
dc.contributor.authorRavisankar, C N
dc.date.accessioned2022-04-01T09:07:10Z
dc.date.available2022-04-01T09:07:10Z
dc.date.issued2021
dc.description.abstractThe aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis, as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and catalase and by lowering the levels of membrane lipid peroxidation.en_US
dc.identifier.citationDOI: 10.1007/s12192-021-01245-xen_US
dc.identifier.urihttp://drs.cift.res.in/handle/123456789/5992
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectBioactivityen_US
dc.subjectGastroprotectiveen_US
dc.subjectGreat hammerhead sharken_US
dc.subjectGross pathologyen_US
dc.subjectHistopathologyen_US
dc.subjectInflammatory markersen_US
dc.titleAntioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced ratsen_US
dc.typeArticleen_US
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