Collagen Biosynthesis in Osteoblast Cells Treated with Fish Collagen Peptides

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dc.contributor.authorHema, G.S
dc.contributor.authorShyni, K
dc.contributor.authorPrasad, M. Manu
dc.contributor.authorNinan, George
dc.contributor.authorMathew, Suseela
dc.date.accessioned2021-10-07T04:38:11Z
dc.date.available2021-10-07T04:38:11Z
dc.date.issued2017
dc.description.abstractCollagen is one of the most widely used biomaterials in tissue engineering and regenerative medicine. To investigate the effect of fish collagen peptides on the formation of collagen proteins by mature osteoblast cells, human osteoblast cells were treated with collagen peptide in both time and dose dependent manner. The stimulatory effect of collagen peptide was confirmed by western blot and immunocytochemistry analysis. The results clearly indicate that the presence of fish collagen peptides led to a dose dependent increase in collagen synthesis by osteoblast cells upto a concentration of 0.6 mg ml-1. However native collagen or collagen free protein hydrolysate failed to stimulate the production of collagen in osteoblast cells. The results show a stimulatory effect of fish collagen peptides on the collagen biosynthesis in osteoblast cells and suggest a possible mechanism for the regulation of collagen turnover in joint tissues.en_US
dc.identifier.citationFishery Tech. 54(2) :107-111en_US
dc.identifier.urihttp://drs.cift.res.in/handle/123456789/4975
dc.language.isoenen_US
dc.publisherSociety of Fisheries Technologists (India),COCHINen_US
dc.subjectFish collagen peptides, osteoblast cells, collagen quantification, western blotting, immunocytochemistryen_US
dc.titleCollagen Biosynthesis in Osteoblast Cells Treated with Fish Collagen Peptidesen_US
dc.typeArticleen_US
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