Biochemical characterization of liver oil of echinorhinus brucus (bramble shark) and its cytotoxic effect on neuroblastoma cell lines (SHSY-5Y)
Biochemical characterization of liver oil of echinorhinus brucus (bramble shark) and its cytotoxic effect on neuroblastoma cell lines (SHSY-5Y)
Date
2016
Authors
Vishnu, K.V.
Ajeeshkumar, K.K.
Chatterjee, N.S.
Suvanish Kumar
Shyni, K.
Jayarani, R.
Suseela Mathew
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Abstract
The objective of the present study was to characterize the liver oil extracted from the deep sea shark, Echinorhinus brucus, caught
from Central Indian Ocean and to evaluate its cytotoxic effect on neuroblastoma cell line (SHSY-5Y). Characterization of liver oil of
Echinorhinus brucus revealed the presence of palmitic acid (15%), oleic acid (12%), stearic acid (8%), docosahexaenoic acid (DHA)
(18%), and eicosapentaenoic acid (EPA) (16%). It was also found to be a good source of squalene (38.5%) and fat soluble vitamins
such as A, D, and K (vitamin A: 17.08mg/100 g of oil, vitamin D: 15.04mg/100 g oil, and vitamin K: 11.45mg/100 g oil). Since it was
found to be rich in essential fatty acids, fat soluble vitamins, and squalene, it can be considered as better dietary supplement.The
oil of Echinorhinus brucus also showed high in vitro cytotoxic effect against the human neuroblastoma cell line (SHSY-5Y) and the
IC50 value laid between 35 and 45 ng.
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Citation
Scientifica, Article ID 6294030, 6 pages http://dx.doi.org/10.1155/2016/6294030