Biochemical studies on the cardioprotective effect of squalene against Isoprenaline-induced myocardial infarction in rats

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dc.contributor.authorFarvin, K.H.S.
dc.contributor.authorAnandan, R.
dc.contributor.authorKumar, S.H.S.
dc.contributor.authorMathew, S.
dc.contributor.authorSankar, T.V.
dc.contributor.authorNair, P.G.V.
dc.date.accessioned2013-12-16T06:54:35Z
dc.date.available2013-12-16T06:54:35Z
dc.date.issued2009
dc.description.abstractThis study was designed to examine the cardioprotective effect of squalene against isoprenaline-induced myocardial infarction in male albino rats. Levels of diagnostic markers [troponin T, homocysteine], lipoproteins [apolipoprotein Al, apolipoprotein B, lipoprotein (a)] (in plasma), total cholesterol, lipid peroxides (in plasma and heart tissue), and endogenous non-enzymatic antioxidants [vitamin C and vitamin EJ (in heart tissue) were determined. Supplementation of squalene at 2% level along with feed for 45 days significantly prevented the isoprenaline-induced elevation in the diagnostic markers in plasma of experimental group of rats. It exerted an antilipidemic action against isoprenaline-induced hypercholesterolemia by maintaining the levels of cholesterol and lipoprotein components at near normalcy. Squalene supplementation exhibited an antioxidant effect against isoprenaline-induced myocardial infarction by blocking the induction of lipid peroxidation. A tendency to prevent the isoprenaline induced reduction in the non-enzymatic antioxidants such as vitamin E and C was also observed. The results of the present study indicate that the cardioprotective effect of squalene might be ascribable to its antilipidemic, antioxidant and membrane stabilizing properties.en_US
dc.identifier.citationFishing Chimes 2009: 46(2), 139-151en_US
dc.identifier.urihttp://hdl.handle.net/123456789/913
dc.language.isoenen_US
dc.publisherSociety of Fisheries Technologists (India), Cochinen_US
dc.subjectSqualeneen_US
dc.subjectmyocardial infarctionen_US
dc.subjectcholesterolen_US
dc.subjectlipid peroxidationen_US
dc.titleBiochemical studies on the cardioprotective effect of squalene against Isoprenaline-induced myocardial infarction in ratsen_US
dc.typeArticleen_US
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FT Vol.46(2)