Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus

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dc.contributor.authorMuthuchelvan, D.
dc.contributor.authorSanyal, A.
dc.contributor.authorSreenivasa, B.P.
dc.contributor.authorSaravanan, P.
dc.contributor.authorDhar, P.
dc.contributor.authorSingh, R.P.
dc.contributor.authorBandyopadhyay, S.K.
dc.date.accessioned2013-12-20T05:32:42Z
dc.date.available2013-12-20T05:32:42Z
dc.date.issued2006
dc.description.abstractThe M gene nucleotide sequence of an Indian peste-des-petits ruminants (PPRV) vaccine virus (‘‘PPRV Sungri/96’’) belonging to Asian lineage was determined. The gene is 1476 nucleotides long with a single open reading frame (ORF). The nucleotide and predicted amino acid sequence was compared with the homologous region of the African Lineage Vaccine virus ‘‘PPRV/Nigeria/75/1’’. The nucleotide sequence of the ‘‘PPRV Sungri/96’’ was 86% identical to that of ‘‘PPRV/Nigeria/75/1’’, while a homology of 93% and 95% could be observed in the ORF and amino acids level, respectively. The M gene encodes a protein of 335 amino acids, with a predicted molecular weight (MW) of 37.8 kDa. The ORF is flanked by a 30 untranslated region of 436 nucleotides and a high level of sequence divergence ( 30%) could be observed in this region between the vaccine viruses of Asian and African lineages. A high degree of conservation of several amino acids of this protein observed previously was also confirmed in this study.en_US
dc.identifier.citationVeterinary Microbiology 2006: 113(1), 83-87en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1012
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMorbillivirusen_US
dc.subjectpeste-des-petits ruminants virusen_US
dc.subjectvaccine virusen_US
dc.subjectm geneen_US
dc.subjectnucleotide sequenceen_US
dc.subjectamino acid sequenceen_US
dc.titleAnalysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virusen_US
dc.typeArticleen_US
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